This quantitative measure is known as the distribution ratio or distribution coefficient.
2.
The distribution coefficient ( D ) considers the partitioning of all ionic species of the compound.
3.
Hence the hydrophobicity of a compound ( as measured by its distribution coefficient ) is a major determinant of how drug-like it is.
4.
A number of methods of measuring distribution coefficients have been developed, including the shake-flask, reverse phase HPLC, and pH-metric techniques.
5.
In the context of pharmacokinetics ( what the body does to a drug ), the distribution coefficient has a strong influence on ADME properties of the drug.
6.
Many other industries take into account distribution coefficients for example in the formulation of make-up, topical ointments, dyes, hair colors and many other consumer products.
7.
Where Kd ( l g-1 ) represents the distribution coefficient, and n is the slope of the straight line giving an indication of the H + / M z + stoichiometry of the exchange reaction.
8.
Furthermore, the lipid solubility of the nonionized species is slight as shown by its low logP value ( log ( 10 ) of the distribution coefficient of the nonionized form between octanol and water ) of-1.43.
9.
According to JiY?H�la's text book, the distribution coefficient K d is the ratio of the soil's radioactivity ( Bq g " 1 ) to that of the soil water ( Bq ml " 1 ).
10.
A drug's distribution coefficient strongly affects how easily the drug can reach its intended target in the body, how strong an effect it will have once it reaches its target, and how long it will remain in the body in an active form.
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